CJC-1295 is a tetrasubstituted 30-amino acid peptide hormone, primarily
functioning as a growth hormone releasing hormone (GHRH) analog. It has D-Ala,
Gin, Ala, and Leu substitutions at positions 2, 8, 15, and 27 respectively.
CJC-1295 is a sterile, non-pyrogenic, white lyophilized powder intended for
subcutaneous or intramuscular injection, after reconstitution with sterile Water for
Mechanism of Action
Basically CJC-1295 is a long acting growth hormone releasing hormone (GHRH)
analog. GHRH, also known as growth hormone releasing factor or somatocrinin,
which is produced by the arcuate nucleus in the hypothalamus. It stimulates
secretion of growth hormone from the pituitary gland and is released in a pulsatile
manner to ultimately stimulate pulsatile release of growth hormone. The result is an
increasing level of both HGH (Human Growth Hormone) and IGF-1 (Insuling-like
One very important advantage of CJC-1295 is that because of its half life, which is
between 10-30 minutes, the user can control the levels of HGH and IGF-1. That
means you can have high levels, when you think its best for results.
The possible benefits of CJC-1295:
- Fat loss
- Better sleep
- Muscle gain
- More energy
- Increased strength
- Stronger bones
- Improved skin tone
- Connective tissues
Special mention should be made about CJC-1295 ability to promote slow wave
sleep. Slow wave sleep is also known as deep sleep and is the portion of sleep
responsible for the highest level of muscle growth and memory retention. SWS is
decreased significantly in older adults and also with people who tend to exercise
later in the evening.
Several studies refer to CJC-1295 action. The 2005 CJC-1295 Study on women who
injected the peptide for 90 days (3 months) indicated several key benefits of the
peptide such as: an increase in athletic physical performance (such as walking and
stair climbing) — all of which occurred 100% as a result of simply taking the peptide
(they did not do any special physical training or dieting in conjunction with the
A 2004 Study, in men, indicated similar findings after 3 months of CJC-1295
injections: a 200% increase (doubling) of both HGH and IGF-1 levels; an increase in
fat free mass (muscle) as well as a reduction in abdominal fat; and an improvement
of physical performance, measured by the time it took to walk 30 minutes and to
ascend four flights of stairs. Once again these excellent results were achieved by
the injections alone, no special diet and weight or cardio training were followed.
The conclusions one can reach is that:
- CJC-1295 (Modified GRF 1-29) is anti-aging as it’s a potent increaser of HGH and
IGF-1 levels which decline with age.
- Results don’t happen overnight and you should take the product for 3 months minimum.
- The peptide is effective on its own (however results would be
far superior with diet and exercise).
- The peptides improve athletic performance, fat loss (particularly stomach fat) and increase muscle mass.
CJC-1295 Peptide is generally very well tolerated by most individuals when used at
the recommended dosages of about 100mcg per injection.
The most common side effect noted is a head “rush” and throbbing of the temples
which occurs about 10 minutes post injection and can last up to 20 minutes. The
side effect is nothing to be concerned about and is simply caused by a release of
GABA (gamma-aminobutyric acid, one neurotransmitter) in the brain — a good sign
the peptide is working to stimulate HGH release.
Water retention and increased tiredness are also noticed by some, with CJC-1295
usage. Water retention can be combated by reducing the sodium (salt) levels in your
diet. Both side effects tend to resolve themselves after a few weeks as the body has
time to adapt. If these side effects are too bothersome, then you may need to
consider injecting only before bed (as morning injections are often the culprit for
Some users also noticed increased hunger, tingling in hands and feet and temporary
irritation (redness and/or lumps) at the injection site.
Instructions for reconstitution
Flip off the top of the peptide vial with your thumb. Use the alcohol swab to wipe the
rubber stopper of the peptide vial. Push the needle of the syringe into the middle of the
rubber stopper so it goes through the rubber and into the vial. Now, while angling the
needle so that the water for injection goes down the side of the glass, rather than
directly into the powder, inject the water for injection into the vial. Repeat this step until
you have the correct amount of water in the vial. The powder will dissolve quickly,
however it can help to gently roll the vial in between your fingers (do not shake the vial
vigorously). Remove the syringe and dispose of it. You should never reuse a syringe.
Recommended dosage of CJC-1295:
- 100mcg (0.10mg) once per day for anti-aging.
- Between 200-300 mcg, divided in two or three doses per day for muscle gain and fat loss, directed via subcutaneous injections.
- After reconstitution, may be stored for a maximum of 14 days in a refrigerator at 2°C — 8°C.
- Store vials in an upright position.
- Store in a refrigerator (2°C — 8°C). Keep in the outer carton in order to protect from light.
- For one month can be stored at room temperature.
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